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{ "code": 200, "msg": "查询成功", "nodes": [ { "uid": "0x1", "info_id": "drug202107051418326655303045", "info_source": "drugbank", "dgraph.type": "Drug", "hasName": "Acetylsalicylic acid", "hasSynonyms": "Acide acétylsalicylique;o-acetoxybenzoic acid;2-Acetoxybenzoic acid;2-Acetoxybenzenecarboxylic acid;Azetylsalizylsäure;Acetylsalicylic acid;O-acetylsalicylic acid;Aspirina;ácido acetilsalicílico;Acetylsalicylsäure;Acidum acetylsalicylicum;o-carboxyphenyl acetate;Aspirin;acide 2-(acétyloxy)benzoïque;Salicylic acid acetate;ASA;Polopiryna;Acetylsalicylate", "hasDescription": { "text": [ { "section_attr": 0, "section_text": "Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) ." }, { "section_attr": 0, "section_text": "Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer <medpeer-reference>refe202107051418314675832720</medpeer-reference>. Aspirin is classified as a non-selective cyclooxygenase (COX) inhibitor <medpeer-reference>refe202107051418307321280400</medpeer-reference><medpeer-reference>,</medpeer-reference><medpeer-reference>refe202107051418312739161520</medpeer-reference> and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others <medpeer-reference>refe202107051418321087632691</medpeer-reference>." }, { "section_attr": 0, "section_text": "Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants ." } ], "reference": [ "refe202107051418312739161520", "refe202107051418307321280400", "refe202107051418321087632691", "refe202107051418314675832720" ] }, "hasType": "Small Molecule", "hasImage": "http://jishu.object.medmdt.net/medicine%2F202107%2F359386e3997ae585172b356391cd6510.svg?OSSAccessKeyId=LTAIpcRXaYR1zBaK&Expires=1627008638&Signature=dMuyP9J64zc91lBMTHaIhFm7tLs%3D", "countInfo": { "Reference": 67, "ClinicalTrial": 974, "Indication": 55, "Drug": 1767, "Target": 70 } }, { "uid": "0x20284", "info_id": "targ202107051520082413639110", "info_source": "drugbank", "dgraph.type": "Target", "hasName": "Multidrug resistance protein 1", "hasSynonyms": "MDR1;3.6.3.44;ATP-binding cassette sub-family B member 1;PGY1;P-glycoprotein 1", "hasGene": "ABCB1", "hasType": "protein", "hasCategory": "transporter", "hasMainFunction": "Xenobiotic-transporting atpase activity", "hasSpecificFunction": "Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells." }, { "uid": "0x20284", "info_id": "targ202107051520082413639110", "info_source": "drugbank", "dgraph.type": "Target", "hasName": "Multidrug resistance protein 1", "hasSynonyms": "MDR1;3.6.3.44;ATP-binding cassette sub-family B member 1;PGY1;P-glycoprotein 1", "hasGene": "ABCB1", "hasType": "protein", "hasCategory": "transporter", "hasMainFunction": "Xenobiotic-transporting atpase activity", "hasSpecificFunction": "Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells." }, { "uid": "0x3a", "info_id": "drug202107051421171081692430", "info_source": "drugbank", "dgraph.type": "Drug", "hasName": "Afelimomab", "hasSynonyms": "Afelimomab", "hasDescription": { "text": [ { "section_attr": 0, "section_text": "Afelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis." } ], "reference": [] }, "hasType": "Biotech", "hasImage": "http://jishu.object.medmdt.net/medicine%2F202107%2Fdb33b6f5c51a8ae2e199f61788e95375.png?OSSAccessKeyId=LTAIpcRXaYR1zBaK&Expires=1627008638&Signature=W%2FvngiKdelv%2B%2F2dV364fVA7Qh1k%3D" }, { "uid": "0x4a3c", "dgraph.type": "ClinicalTrial", "hasName": "Phase 2B Study to Evaluate the Efficacy of PB2452 in Reversal of Ticagrelor in Subjects Aged 50-80 Years" } ], "links": [ { "source": "0x1", "target": "0x4a3c" }, { "source": "0x1", "target": "0x3a" }, { "source": "0x1", "target": "0x20284" }, { "source": "0x1", "target": "0x20284" } ], "categories": [ "ClinicalTrial", "Drug", "Target" ] }

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